Today I wasted a lot of time to understand why, the code I wrote to implement PlayReady in a Windows 8 App didn’t work. I have ran the code lot of times, making changes to handle obscure hypothesis, just because my application was failing to load a DRM protected stream. When I finally found the error code issued by the MediaFailed event I went on the right way:
MF_MEDIA_ENGINE_ERR_SRC_NOT_SUPPORTED : HRESULT – 0x800700C1
I convinced myself that the problem wasn’t in the code but probably in the context I was compiling, this because the error 0x800700C1 means “is not a valid Win32 application”.
Comparing the project configuration with the one in the samples, I found the answer in a simple flag in the project configuration:

The “prefer 32-bit” flag is a new entry in the projects that target Microsoft .NET Framework 4.5. Its meaning is explained well in this post but in a few words in my case it was forcing the compiler to output to x86 (32-bit) instead of x64. Unfortunately PlayReady only supports 64bit runtime so, when the application ran it failed with the code I reported above.
So, when you’ll have to write applications that take advantage of the PlayReady SDK, please always remember to clear this flag because it is the sole way to have it working.